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环孢霉素A(Cyclosporin A—CSA)系多种真菌的代谢产物,是一种环状11—肽(endocapeptide),由几种N-甲基化氨基酸和一个迄今未知的氨基酸组成。它自七十年代问世以来,在动物实验和一些临床实践中,业已证明是一个很强的免疫抑制药。一、作用机理的研究 Borel(1976)报告当环孢霉素A与同种异体肿瘤细胞一起给予鼠时,防止了致敏毒性细胞的产生;新近又发现它亦能抑制延迟过敏反应的发生。进一步的研究证明环孢霉素A是一种新的抗淋巴细胞药,它对T-细胞有特殊的选择性抑制作用。试管中实验结果说明,对T-细胞
Cyclosporin A-CSA, a metabolite of many fungi, is a cyclic endocapeptide consisting of several N-methylated amino acids and a hitherto unknown amino acid. It has been shown to be a potent immunosuppressant in animal experiments and in some clinical practice since its introduction in the 1970s. First, the mechanism of action Borel (1976) reported that when cyclosporine A and allogeneic tumor cells administered to mice, to prevent the generation of sensitized toxic cells; recently also found that it also can inhibit the occurrence of delayed allergic reactions. Further studies show that cyclosporin A is a new anti-lymphocyte drug, it has a special selective inhibition of T-cells. Experimental results in tubes indicate that T-cells