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目的分析感染科医务人员甲型H1N1流感血清抗体消长变化,为制定免疫策略提供依据。方法 339名自愿接种甲型H1N1流感疫苗的感染科医务人员在接种后6个月、1年、2年采集血清,63名不愿意接种的感染科医务人员在相同时间采血,分别检测其IgM及IgG抗体。结果接种组与未接种组比较,接种后6个月、1年及2年时,其IgM抗体和IgG抗体水平和阳性率差异均有统计学意义(P<0.05);接种组IgM抗体水平在接种后6个月最高(A值1.00±0.22),而IgG抗体在接种后1年最高(A值1.02±0.16),其IgM和IgG抗体水平在各个时间段之间的两两比较差异均有统计学意义(P<0.001);Logistic回归分析在接种后的6个月、1年和2年,性别和年龄两个变量差异均无统计学意义(P>0.05)。结论甲型H1N1流感疫苗的免疫原性较理想,尤其是感染科医务人员,目前易感人群又在不断增加,有必要将其纳入常规接种及加强免疫。
Objective To analyze the change of serum antibody of Influenza A (H1N1) in medical staff in infectious diseases and provide the basis for the development of immunization strategy. Methods A total of 339 infective medical staff who inoculated influenza A (H1N1) vaccine voluntarily collected serum at 6 months, 1 year and 2 years after inoculation, and 63 unwilling infectious patients took blood at the same time to detect IgM and IgG antibody. Results The level of IgM antibody and IgG antibody and the positive rate of IgM antibody and IgG antibody in vaccinated group were significantly different from those in non-vaccinated group (P <0.05) at 6 months, 1 year and 2 years after vaccination. The IgM antibody level in vaccinated group was At 6 months after inoculation, the highest level was found (A = 1.00 ± 0.22), while the level of IgG antibody at 1 year after inoculation was the highest (A = 1.02 ± 0.16). The difference of IgM and IgG antibody levels among different time periods was significant Statistical significance (P <0.001). Logistic regression analysis showed no significant difference in gender and age at 6 months, 1 year and 2 years after inoculation (P> 0.05). Conclusions The immunogenicity of Influenza A (H1N1) vaccine is better than that of other infectious diseases, especially for medical staff in infectious diseases. At present, the number of susceptible people is on the rise again. It is necessary to include them in routine vaccination and immunization.