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目的：探讨放射免疫显像（ＲＩ）对诊断大肠癌的价值和肿瘤大小、癌组织ＣＥＡ及分布、血清ＣＥＡ对显像结果的影响。方法：用９９ｍＴｃ标记的抗ＣＥＡＭｃＡｂＣ５０对２７例病人（２４例大肠癌及３例非大肠癌）进行放射免疫显像。用链霉菌素生物素过氧化酶免疫组织化学染色检查２０例大肠癌组织ＣＥＡ含量。结果：２４例大肠癌病人显像灵敏度为７１．４％（３０／４２）。显像阳性组，阴性组癌灶大小分别为６．９０±０．８７ｃｍ，３．６０±０．８１ｃｍ（Ｐ＜０．０５），血清ＣＥＡ分别为３０．３±６．３４μｇ／Ｌ和４２．６±１５．３４μｇ／Ｌ（Ｐ＞０．０５）。显像灵敏度与肿瘤组织ＣＥＡ含量、分布有关（Ｐ＞０．０５）。结论：ＲＩ对大肠癌的诊断有一定临床价值。肿瘤大小、癌组织ＣＥＡ含量及定位分布是影响显像灵敏度的重要因素，血清ＣＥＡ水平高低不影响显像结果。
Objective: To investigate the value of radioimmunoimaging (RI) in the diagnosis of colorectal cancer and tumor size, CEA and distribution of cancer tissue, serum CEA imaging results. Methods: Radioimmunoimaging was performed on 27 patients (24 with colorectal cancer and 3 with non-colorectal cancer) with 99mTc-labeled anti-CEAMcAbC50. Streptozotocin biotin peroxidase immunohistochemical staining of 20 cases of colorectal cancer tissue CEA content. Results: The sensitivity of imaging in 24 patients with colorectal cancer was 71.4% (30/42). The size of the lesion in the positive group and the negative group were 6.90 ± 0.87cm and 3.60 ± 0.81cm (P <0.05), the serum CEA were 30.3 ± 6.34μg / L and 42 .6 ± 15.34μg / L (P> 0.05). Imaging sensitivity and CEA content of tumor tissue and distribution (P> 0.05). Conclusion: RI has some clinical value in the diagnosis of colorectal cancer. Tumor size, CEA content and localization of cancerous tissue are important factors that affect the imaging sensitivity. Serum CEA level does not affect the imaging results.