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阿司匹林通过抑制血小板环氧化酶及血栓素TXA2的形成完成其抗血栓形成的作用。但即使口服很小剂量的阿司匹林也会抑制前列环素PGI2的形成及引起胃肠道反应。本试验拟将皮肤作为持续小剂量使用阿司匹林的新途径,选择性抑制人体血小板环氧化酶的形成。1方法与结果溶于异丙醇、乙
Aspirin completes its antithrombotic effect by inhibiting the formation of platelet cyclo-oxygenase and thromboxane TXA2. However, even a small oral dose of aspirin can inhibit PGI2 prostacyclin formation and cause gastrointestinal reactions. This experiment intends to use the skin as a new way to continue aspirin in small doses and selectively inhibit the formation of human platelet cyclooxygenase. 1 Methods and Results Dissolved in isopropanol, B.