【摘 要】
：
Crimean-Congo hemorrhagic fever (CCHF) caused by the CCHF virus (CCHFV) is a tick-borne natural focal disease with a mortality rate of approximately 50％.CCHFV is widely prevalent in Africa,southern Asia,the Middle East,and southeast Europe.CCHF outbreaks
【机 构】
：
State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan 43
论文部分内容阅读
Crimean-Congo hemorrhagic fever (CCHF) caused by the CCHF virus (CCHFV) is a tick-borne natural focal disease with a mortality rate of approximately 50％.CCHFV is widely prevalent in Africa,southern Asia,the Middle East,and southeast Europe.CCHF outbreaks have been reported previously in Xinjiang province,China,especially in its southern region.Epidemiological surveys conducted on ticks and animals have revealed the presence of CCHFV strains in ticks,rodents,and infected individuals from cities and counties in southern Xinjiang.Phylogenetic analyses revealed that the Chinese CCHFV strains belong to one genotype,based on complete sequences of the S segments of its negative-stranded RNA genome.The present study reports two new CCHFV strains isolated from Hyalomma asiaticum asiaticum ticks collected from Fukang City and Wujiaqu City in the northern region of Xinjiang.Viral characteristics and their evolutionary relationships were analyzed through metagenomic and reverse-transcription PCR analyses;these analyses indicated that the genotype of both strains was different from that of other Chinese strains.Furthermore,previous reports of CCHFV in Xinjiang were reviewed and phylogenetic analyses were performed.CCHFV was found to prevail in Fukang City in Junggar Basin for more than 20 years,and that Fukang City and Wujiaqu City are considered natural reservoirs of different genotypes of CCHFV strains.Our findings facilitate the understanding of CCHFV distribution in Xinjiang province and provide insights into the evolutionary relationships among Chinese CCHFV strains.
其他文献
Cancer cell lines have been used widely in cancer biology,and as biological or functional cell systems in many biomedical research fields.These cells are usually defective for many normal activities or functions due to significant genetic and epigenetic c
Rabies is a zoonotic disease that still causes 59,000 human deaths each year,and rabies vaccine is the most effective way to control the disease.Our previous studies suggested that the maturation of DC plays an important role in enhancing the immunogenici
A novel PRRSV strain was isolated in China that was genetically similar to the NADC30 strain which is reported to have spread throughout China.The objective of the present study was to evaluate the cross-protective efficacy of the live vaccine TJM-F92 in
Oxymatrine (OMT),as the main active component of Sophoraflavescens,exhibits a variety of pharmacological properties,including anti-oxidative,anti-inflammatory,anti-tumor,and anti-viral activities,and currently is extensively employed to treat viral hepati
Viruses evolve rapidly and continuously threaten animal health and economy,posing a great demand for rapid and efficient genome editing technologies to study virulence mechanism and develop effective vaccine.We present a highly efficient viral genome mani
Since the publication of the DRiP (defective ribosomal product) hypothesis in 1996,numerous studies have addressed the contribution of DRiPs to generating viral antigenic peptides for CD8+ T cell immunosurveillance.Here,we review studies characterizing th
Hepatitis B virus (HBV) infection is one of the major problems that threatens global health.There have been many studies on HBV,but the relationship between HBV and host factors is largely unexplored and more studies are needed to clarify these interactio
Dear Editor,rnH7N9 is a recently identified subtype of influenza A virus that caused a major outbreak in humans in China in 2013.According to the latest data provided by the Chinese Center for Disease Control and Prevention (http://www.moh.gov.cn/zwgk/yqb
The recent outbreak of coronavirus disease (COVID-19) caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has already affected a large population of the world.SARS-CoV-2 belongs to the same family of severe acute respiratory s
Herpes simplex virus 1 (HSV-1),a member of α herpesviruses,shows a high infectivity rate of 30％-60％ in populations of various ages.Some herpes simplex (HSV) vaccine candidates evaluated during the past 20 years have not shown protective efficacy against v