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目的比较高、低剂量布地奈德混悬液(普米克令舒)雾化吸入治疗小儿毛细支气管炎的有效率、住院时间及不良反应。方法将收治的84例毛细支气管炎急性发作的患儿随机分为两组,在常规治疗的基础上,治疗组予布地奈德混悬液1 mg/次雾化吸入,每2 h一次,连用3次,之后1 mg/次,每6 h一次;对照组予布地奈德混悬液雾化吸入0.5mg/次,每12 h一次,疗程5～7 d。两组每次雾化同时吸入特布他林2.5 mg。观察两组的有效率、住院时间及不良反应。结果治疗组有效率显著优于对照组,住院时间显著缩短,差异均有统计学意义。两组均未见明显不良反应。结论高剂量布地奈德混悬液雾化吸入治疗小儿毛细支气管炎起效快,疗效显著,可缩短患儿住院时间,同时不良反应少,安全有效。
The purpose of higher, low-dose budesonide suspension (Pulmicort respules) inhalation treatment of pediatric bronchiolitis efficiency, length of stay and adverse reactions. Methods Eighty-four children with acute episode of bronchiolitis were randomly divided into two groups. On the basis of routine treatment, the treatment group was given budesonide suspension 1 mg / time for inhalation once every 2 hours, 3 times, then 1 mg / time, once every 6 h; control group budesonide suspension inhalation 0.5mg / time, every 12 h, treatment of 5 ~ 7 d. Both groups inhaled terbutaline 2.5 mg concurrently with each inhalation. The two groups were observed the efficiency, hospital stay and adverse reactions. Results The treatment group was significantly better than the control group, hospitalization time was significantly shorter, the differences were statistically significant. No obvious adverse reactions were found in both groups. Conclusion The high dose budesonide suspension atomization inhalation therapy for children with bronchiolitis has rapid onset and significant curative effect, which can shorten the hospitalization time of patients with less adverse reactions and is safe and effective.