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白塞氏病的病理生理学不明.然流行病学,临床和实验室资料显示体质和环境的重要性.特殊的体质肯定有遗传和免疫的基础,后者可为先天性或获得性.遗传学支持者引证男性,家族性及HLA-B_5基因多见.免疫学支持者根据组织学示血管炎和生物学的紊乱,认为本病系一免疫障碍性疾病.实际上血管炎是本病的解剖学基础,涉及所有受累器官:皮肤、眼、粘膜、神经系统、滑膜、肾的动脉和静脉.表现为血管周围的多形性浸润,以淋巴细胞或多形核白细胞为主,视损害的阶段而定;内皮细胞肿胀并增殖使血管腔完全或部分阻塞;有时细动脉有纤维蛋白样坏死.在皮损中血管周围的浸润是由破碎的多形核白细胞组成,即所谓变应性血管
The pathophysiology of Behcet’s disease is unknown, but epidemiological, clinical, and laboratory data show the importance of the physical and environmental determinants of certain genetic and immunological affirmations, which may be congenital or acquired. Proponents cite men, familial and HLA-B_5 gene more common immunological supporters based on histological vasculitis and biological disorders, that the disease is an immune disorder. In fact vasculitis is the anatomy of the disease Basis for learning, involving all affected organs: the skin, eyes, mucous membranes, nervous system, synovium, renal arteries and veins. Peripheral vascular performance of pleomorphic infiltration, mainly to lymphocytes or polymorphonuclear leukocytes, depending on the damage Stage may be; endothelial cell swelling and proliferation of vascular cavities completely or partially obstruction; sometimes fine arteries fibrinoid necrosis. Perivascular infiltration in the lesion is composed of broken polymorphonuclear leukocytes, the so-called allergic vessels