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吡哆醇(维生素B_6)是一种人体必需的水溶性维生素,为一种辅酶,参与许多脱羧基和转氨基的反应。据认为是安全的药物,不会伴发神经毒作用。可用以治疗经前期综合征、腕管综合征。极大剂量(600～3,000mg/d)用于治疗精神分裂症及有孤独癖的儿童,未见报告副作用。最近有人建议每日剂量高达2g以治疗儿童运动机能亢进。本文证实大剂量吡哆醇可引起严重的神经毒性。作者报道7例成年人(男2、女5例)使用大剂量吡哆醇,2～6g/d,2～40个月后发生渐进性感觉性共济失调,肢体远端重度位置觉和振动觉障碍。触觉、温度觉及痛觉几无受影响。除趾伸肌轻度受累外,无力并非本病的特征。所有腱反射均减弱或消失。除3例有暂时性Lhermitte氏征外,未发现中枢
Pyridoxine (vitamin B_6) is a water-soluble vitamin essential for human body. It is a coenzyme involved in many decarboxylation and transamination reactions. It is considered a safe drug, not accompanied by neurotoxic effects. Can be used to treat premenstrual syndrome, carpal tunnel syndrome. Very high doses (600-3,000 mg / d) were used to treat schizophrenia and children with loneliness, with no reported side effects. Recently, it has been suggested that daily doses up to 2g to treat children with hyperactivity. This article confirms that high doses of pyridoxine can cause severe neurotoxicity. The authors report that 7 adults (2 males and 5 females) were treated with high-dose pyridoxine 2-6 g / d, progressive sensory ataxia 2-40 months later, severe distal limb sensation and vibration Hindrance. Tactile, temperature and pain feel a little affected. Except for mild extensor phalangeal involvement, weakness is not a hallmark of the disease. All tendon reflexes diminish or disappear. In addition to three cases have a temporary Lhermitte’s sign, no central found