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苯妥英静脉注射后迅速进入脑组织,若剂量较小,随着药物的重新分布,脑和血浆内浓度很快下降,苯妥英的神经生理作用即消失.如用以紧急治疗痉挛发作和癫痫持续状态,需用足大剂量苯妥英以使迅速达到和维持有效浓度.血清内苯妥英浓度高时其半衰期延长,一次大剂量静脉注射后可获得充分的血清浓度,从而可避免肌内注射的合并症.但据报告静脉给予本药可发生低血压,心律失常和死亡.因此有人反对大剂量苯妥英静脉注射.本文报告应用大剂量苯妥英静脉注射的临床并发症和血清药物浓度的测定.为了紧急处理频繁性痉挛发作病人和防止蛛网膜下腔出血病人痉挛发作,对139例成年病人作大剂
Phenytoin rapidly into the brain tissue after intravenous injection, if the dose is small, with the redistribution of drugs, brain and plasma concentrations decreased rapidly, the neurophysiological role of phenytoin disappeared, such as emergency treatment for spastic seizures and status epilepticus, Need to use large doses of phenytoin in order to quickly reach and maintain the effective concentration of high concentrations of phenytoin in serum when its half-life is prolonged, after a large dose of intravenous injection to obtain adequate serum concentration, which can avoid the complications of intramuscular injection.But according to Reported intravenous administration of the drug can occur hypotension, arrhythmia and death.So people are opposed to intravenous bolus doses of phenytoin.This paper reports the clinical application of high doses of phenytoin intravenous injection and serum drug concentration determination.In order to emergency treatment of frequent spasms Patients and prevention of spasm episodes in patients with subarachnoid hemorrhage, 139 adult patients for large doses