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目的探讨氨茶硷和肾上腺素联合应用在早期心肺复苏的疗效。方法将51例心脏停搏患者随机分为治疗组(26例)和对照组(25例)。两组肾上腺素用法相同,治疗组同时给予氨茶硷0.25g静脉注射,5min后重复使用,最大剂量为1.0g,直至心电活动恢复。比较2组心电活动、自主循环恢复和自主循环恢复时间以及存活率。结果治疗组和对照组心电活动恢复率分别为88.46%(23/26)、52.0%(13/25),(p<0.05);自主循环恢复率分别为69.23%(18/26)、36.0%(9/25),(p<0.05);自主循环恢复时间分别为(5.63±3.83)min、(11.78±5.97)min,(p<0.005);存活率分别为34.62%(9/26)、16.0%(4/25)(p>0.05)。结论氨茶硷和肾上腺素联合应用在早期心肺复苏的疗效优于单独使用标准剂量肾上腺素。
Objective To investigate the curative effect of aminophylline and epinephrine combined with early cardiopulmonary resuscitation. Methods 51 patients with cardiac arrest were randomly divided into treatment group (26 cases) and control group (25 cases). Two groups of the same usage of epinephrine, the treatment group also given intravenous injection of 0.25g ammonia aminophylline, 5min after repeated use, the maximum dose of 1.0g, until the ECG activity recovery. Two groups of ECG activity, spontaneous circulation recovery and spontaneous circulation recovery time and survival rate were compared. Results The recovery rates of ECG in treatment group and control group were 88.46% (23/26) and 52.0% (13/25) respectively (p <0.05), and the recovery rates of spontaneous circulation were 69.23% (18/26) and 36.0 (5.63 ± 3.83) min, (11.78 ± 5.97) min, respectively (p <0.005); the survival rates were 34.62% (9/26), respectively , 16.0% (4/25) (p> 0.05). Conclusion The combination of aminophylline and epinephrine is superior to early use of standard-dose epinephrine alone in early cardiopulmonary resuscitation.