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目前,认为再生障碍性贫血(简称再障)的原因有干细胞损害,骨髓造血微循环的损害及存在着针对造血干细胞的抑制细胞等。尽管病因不同,但是用HLA(人体白细胞抗原)一致的同胞做同种骨髓移植治疗重型再障却收到良好的效果,长期生存率可达75%。最近作者对没检出抑制细胞的7岁重型再障女孩,移植了HLA、ABO血型完全一致的哥哥的骨髓,结果患儿的骨髓造血功能恢复了正常。本文讨论了粒细胞系统造血干细胞的CFU-c(培养集落形成细胞),刺激因子的CSA(集落刺激活性)以及红细胞系统干细胞的增殖因子BPA(释放促进活性)。结果:(1)骨髓和CFU-c的变化;在骨髓移植前,粒细胞和幼红细胞系为12.8%。移植后12天,骨髓有核细胞虽然明显增加,但是粒细胞系和幼红细胞系也增到66.8%。以后骨髓有核细胞继续增加,
At present, it is thought that the causes of aplastic anemia (referred to as aplastic anemia) stem cell damage, bone marrow hematopoietic microcirculation damage and the presence of inhibiting cells for hematopoietic stem cells. Despite the different etiologies, using HLA-identical siblings with a homogeneous bone marrow transplant to treat aplastic anemia has received good results with a long-term survival of up to 75%. Recently, the author of the 7-year-old girl with severe aplastic anemia did not detect suppressor cells, transplantation of HLA, ABO blood type identical brother’s bone marrow, the results of bone marrow hematopoietic function in children returned to normal. This article discusses CFU-c (cultured colony forming cells) of granulocyte-derived hematopoietic stem cells, CSA of stimulating factors (colony stimulating activity), and proliferation factor BPA (release-promoting activity) of erythrocyte stem cells. RESULTS: (1) Changes in bone marrow and CFU-c; before bone marrow transplantation, the granulocytes and erythroid lines were 12.8%. 12 days after transplantation, although the number of bone marrow nucleated cells increased significantly, the number of granulocytic and erythroid lines increased to 66.8%. After the bone marrow cells continue to increase,