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一、引言心肌收缩力的严重损害可引起慢性心力衰竭,心脏不能把血液泵至外周部位,结果满足不了机体代谢需要。心力衰竭的起因有心肌局部缺血、高血压、非阻塞性心肌病变及先天性心脏病等。慢性心力衰竭传统上单用或合并应用正性肌力药(增强心肌收缩力)、利尿药(减轻容量负荷)和外周血管扩张药(减轻心脏前和/或后负荷)。本文将主要介绍正性肌力药以及外周血管扩张药,包括临床应用的药物、有可能应用的新药和有特殊机理而又可能有效的药物。
First, the introduction of myocardial contractility serious damage can cause chronic heart failure, the heart can not pump blood to peripheral sites, the result can not meet the body’s metabolic needs. The causes of heart failure are myocardial ischemia, hypertension, non-obstructive cardiomyopathy and congenital heart disease. Chronic heart failure has traditionally been used alone or in combination with inotropic agents (to enhance myocardial contractility), diuretics (to relieve capacity load) and peripheral vasodilators (to reduce pre-cardiac and / or post-stress). This article will focus on inotropic drugs and peripheral vasodilators, including clinical applications of drugs, the possibility of the application of new drugs and may have a special mechanism and may be effective drugs.