Th17细胞与Th1细胞在慢性阻塞性肺疾病炎症发病机制中的调控作用

• 作 者: 段敏超 韩伟
• 机 构: 530001,南宁市第八人民医院呼吸内科
• 出 处: 国际免疫学杂志
• 发表日期: 2016年6期
• 关键词: T helper cells Cytokines Chronic obstructive pulmonary disease Inflammation Immu

慢性阻塞性肺疾病(COPD)发病的分子机制目前仍不甚清楚,大量证据表明,T淋巴细胞介导的免疫反应贯穿于COPD的各个阶段,导致炎症反应持续放大.近来研究发现,Th1细胞和Th17细胞均参与了COPD的免疫发病过程,通过相互间作用调控COPD的炎症反应.因此,深入了解COPD炎症发病过程中Th17、Th1细胞免疫应答特征、分化及调控功能,对探讨COPD的致病机制以及免疫调节治疗的靶点具有重要意义.“,”Chronic obstructive pulmonary disease (COPD)is more and more common.However,the molecular and cellular mechanisms that are responsible for the development of COPD are not well understood.Accumulating evidence has shown that both Th1 and Thl7 subsets plays a key role in regulation of the immune response in COPD.Understanding the immune response,differentiation and regulation of Th17 and Th1 cells in the COPD contribute to explore the pathogenic mechanisms of COPD and therapeutic approach for COPD.