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由于目前还不清楚白血病细胞通常不能存活的原因,因此骨髓长期培养(LTBMC)能否作为白血病患者自体骨髓移植前骨髓净化的一种手段,是本文探讨的目的。一、白血病细胞在LTBMC中的生长特点 1985年Coulombel等首次报导AML患者骨髓细胞经LTBMC后,白血病细胞明显减少,而使正常造血细胞占优势;另外,Ph′阳性的CML细胞经3～4周的LTBMC后可产生明显数量的ph′阴性细胞。本文作者的实验结果也证实了这一发现,他们培养AML患者骨髓细胞,其中50％的病例的白血病细胞
Since it is unclear why leukemic cells usually do not survive, whether bone marrow long-term culture (LTBMC) can be used as a means of bone marrow purification before autologous bone marrow transplantation in leukemia patients is the purpose of this article. 1. Growth characteristics of leukemia cells in LTBMC In 1985, Coulombel et al reported for the first time that the leukemia cells were significantly reduced in LMCs from patients with AML and that normal hematopoietic cells predominated; in addition, Ph’ positive CML cells were treated for 3 to 4 weeks. The LTBMC can produce a significant number of ph’-negative cells. The authors’ experimental results also confirmed this finding. They cultured bone marrow cells in AML patients, and 50% of them were leukemia cells.