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对１１５例食管癌病人被切除的３８１枚淋巴结经常规病理检查无癌转移者进一步做免疫组化研究。这些淋巴结经连续切片、抗角蛋白血清免疫组化染色进行复查，发现其中２６例病人（２２．６％）的２７枚淋巴结（７％）存在单个或小团癌细胞微小癌转移灶。隐匿性微小癌转移的检出率不同民族、性别间差异无统计学意义。淋巴结内隐匿性癌转移灶的存在，涉及到癌细胞广泛扩散和转移的基本规律、临床分期、治疗及评价预后等重大肿瘤发展生物学问题。对此进行深入研究有助于探索控制恶性肿瘤发展的新途径。
A further immunohistochemical study was performed on 381 lymph node removed from 115 esophageal cancer patients undergoing routine pathological examination without metastasis. These lymph nodes were serially sectioned and subjected to anti-keratin serum immunohistochemical staining for review. Twenty-seven patients (22.6%) of 27 lymph nodes (7%) were found to have small or large tumor metastases. The detection rate of occult microcarcinoma metastasis was not statistically different among nationalities and genders. The existence of occult cancer metastases in lymph nodes involves the development of basic cancer biology, clinical stages, treatment, and evaluation of prognosis and other major tumor development biology problems. In-depth research on this can help to explore new ways to control the development of malignant tumors.