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本文用恶性疟原虫环状体感染的红细胞表面抗原(RESA)免疫小鼠,并测定免疫小鼠和非免疫小鼠中对RESA抗原重复序列表位具有特异反应性的抗体形成细胞前体(AFCp)的频率,且作B细胞克隆组分分析,借此探讨RESA重复序列表位在疟原虫免疫逃避过程中所起的作用。作者用氨基末端为半胱氨酸的RESA 3′重复序列表位(8×4-mer)合成肽免疫CBA小鼠,另以钥孔(虫戚)血兰蛋白(Keyhole limpet haemocyanin,KLH)与8×4-mer结合后的KLH-4-mer结合物免疫的CBA小鼠,或仅注射弗氏或
In this paper, mice were immunized with erythrocyte surface antigen (RESA) infected with P. falciparum ring and antibody precursor cells (AFCp) with specific reactivity to the RESA antigen repeat epitopes in immunized and non-immunized mice ), And analyzed the components of B cell clones to explore the role of RESA repeat epitopes in immune evasion of Plasmodium. In this study, CBA mice were immunized with 8 × 4-mer synthetic amino-terminal RESA 3 ’repeats. Keyhole limpet haemocyanin (KLH) CBA mice immunized with 8x4-mer conjugated KLH-4-mer conjugate or CBA mice injected with either Freund’s or