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血小板活化在生理止血及病理血栓形成中起重要作用。血小板的活化,有向血管壁粗糙面的粘附、粘性变性、凝聚释放反应及产生前列腺素的中间代谢产物。释放反应是从致密颗粒释出 ADP、ATP、5-羟色胺等,从α-颗粒释放出血小板第4因子(PF4)、β-血栓球蛋白(β-TG)、血小板增殖因子及酸性水解酶等。测定释出物中的血小板特异蛋白(β-TG 及PF_4)在血浆中的浓度可以反映机体内血小板的释放反应,对诊断血栓栓塞性疾病及血栓好发状态起重要作用。
Platelet activation plays an important role in physiological hemostasis and pathological thrombosis. Platelet activation, there are rough adhesion to the vascular wall, viscous degeneration, condensation release reaction and produce prostaglandin intermediate metabolites. Release reaction is released from the dense particles of ADP, ATP, serotonin, released from the α-platelet factor 4 (PF4), β-thromboglobulin (β-TG), platelet proliferation factor and acid hydrolase . Determining the concentration of platelet-specific proteins (β-TG and PF_4) in the plasma can reflect the platelet release response in vivo and plays an important role in the diagnosis of thromboembolic diseases and the development of thrombus.