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用5％牛磺胆酸钠-胰蛋白酶溶液作为强刺激物直接注入大鼠胰导管系统,制成急性出血坏死性胰腺炎模型。若于48h前向胰导管内预先给予0.1％、0.2％或0.4％的低浓度牛磺胆酸钠-胰蛋白酶溶液作为弱刺激物,能使随后给予的强刺激物所致的损伤大大减轻,使病鼠死亡率由对照组的100％分别降低到27％、17％和17％;血清淀粉酶浓度升高的幅度由对照组的4680U/100ml血清降低到1990、2180和2710U/100ml血清。胰腺组织学切片检查可见,病变由急性出血坏死性胰腺炎转变为轻度急性胰腺炎或向慢性胰腺炎转化。这项结果提示:预先给予弱刺激可使胰腺外分泌细胞对随后给予的强刺激产生适应性细胞保护作用,其机制尚待探索。
Acute hemorrhagic necrotizing pancreatitis model was made by injecting 5% sodium taurocholate-trypsin solution into rat pancreatic duct directly as a strong stimulus. If 48 hours prior to the pancreatic duct pre-given 0.1%, 0.2% or 0.4% of the low concentration of sodium taurocholate trypsin solution as a weak stimulus, can be subsequently given a strong irritant-induced damage greatly reduced, The mortality of the mice was decreased from 100% in the control group to 27%, 17% and 17% respectively. The increase of serum amylase concentration was reduced from 4680U / 100ml serum in the control group to 1990, 2180 and 2710U / 100ml serum. Pancreatic histological examination showed that the lesion was changed from acute hemorrhagic necrotizing pancreatitis to mild acute pancreatitis or to chronic pancreatitis. The results suggest that pretreatment of weak stimuli may make pancreatic exocrine cells produce adaptive cytoprotective effects on subsequent strong stimuli, and the mechanism remains to be explored.