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2型糖尿病是一种年龄、肥胖及炎症相关性疾病。随着年龄增长以及脂肪组织的积聚，炎性细胞激活以及炎性因子释放导致胰岛素靶细胞敏感性下降，形成胰岛素抵抗，即2型糖尿病前期。沉默信息调节因子相关酶类1（SIRT1）是一种组蛋白脱乙酰化酶，在哺乳动物糖脂能量代谢和生命活动中扮演重要角色；核因子κB可诱导多种炎性细胞因子，是炎性反应和细胞生存的枢纽环节。该文主要讨论SIRT1通过调节核因子κB的表达作用于2型糖尿病的发病，为2型糖尿病的预防以及治疗提供更多理论基础。“,”Type 2 diabetes mellitus is a metabolic disorder relevant to aging,obesity,and inflammation. Due to aging and accumulation of fat tissues ,insulin resistance,which is the prophase of type 2 diabetes mel-litus results from the sensitivity decrease of insulin target cells caused by the activation of inflammatory cells and release of inflammatory factors .SIRT1 ( silent information regulator related enzymes-1 ) is a histone deacetylase which plays important role in the energy metabolism of glucose and lipid and life span .NF-kap-paB can induce various inflammatory cytokines,it is the key point of inflammation and cell survival.Here is to make a review of the relationship between SIRT1/NF-κB signal pathway and type 2 diabetes mellitus,in order to provide theoretical basis for the prevention and treatment for type 2 diabetes mellitus.