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为进一步研究抗着丝粒抗体(ACA)是否对CREST综合征是特异性的,以及ACA的存在与系统性硬化症临床特征的联系,确定是否ACA阳性病例是肢端硬化症病谱内的一个不同的亚型,作者以HEP-2细胞为底物,用间接免疫荧光法对84例肢端硬化症,30例弥漫性硬皮病,10例肢端硬化症——弥漫性硬皮病的过渡病例,54例雷诺氏病(RD),5例MCTD,21例SLE和20例RA病人进行了研究。结果发现84例肢端硬化症或CREST综合征病人中21例(25％)ACA(+),54例RD病人中4例ACA(+),其他患者ACA均(-)。作者又将肢端硬化症中ACA(+)与ACA(-)两组病人进行了比较。发现两组的性别、平均年龄、雷诺氏现象和硬化的平均病期无明显差异,但ACA(+)患者面部、手指、双前臂的严重皮肤受累较ACA(-)患者明显为少。ACA(+)组指趾硬化或硬化性水肿不太明显,无手指挛缩或固定。总的皮肤受累的
To further investigate whether anti-centromere antibody (ACA) is specific for CREST syndrome and the association of the presence of ACA with the clinical features of systemic sclerosis, it is determined whether an ACA-positive case is one within the spectrum of acral sclerosis Different subtypes, the authors HEP-2 cells as a substrate, indirect immunofluorescence 84 cases of sclerosis, 30 cases of diffuse scleroderma, 10 cases of sclerosis - diffuse scleroderma Transitional cases, 54 cases of Raynaud’s disease (RD), 5 cases of MCTD, 21 cases of SLE and 20 cases of RA patients were studied. Results ACA (+) was found in 84 patients with extremity sclerosis or CREST syndrome, and ACA (+) in 4 of 54 patients with RD. ACA was found in all other patients (-). The authors compared ACA (+) and ACA (-) patients with acromegaly. There was no significant difference in mean gender, mean age, Raynaud’s phenomenon and mean duration of hardening between the two groups. However, severe skin involvement on the face, fingers, and both forearms in ACA (+) patients was significantly less than in ACA (-) patients. ACA (+) group refers to the sclerosis or sclerosis edema is not obvious, no contracture or fixed fingers. Total skin involvement