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复发性口腔生殖器溃疡(OGU)足Behcet综合征的主要症状,但常是孤立的表现。大多数治疗(包括大剂量皮质类固醇和细胞毒药物)疗效不佳。作者用反应停治疗15例重症OGU成功,并对反应停的可能作用方式作了一些探索。反应停对OGU的疗效已有报告,但机理不明。Sheskin(1965)用反应停治疗瘤型麻风反应有效,后者以皮肤内中性白细胞积聚和免疫复合物损伤为特征。Jorizzo等认为阿夫他和Behcet综合征的其它损害与麻风反应机理有相似之处。因此作者报告了临床疗效,并用两个大鼠模型研究了反应停对炎症损害中中性白细胞积聚的影响。
Recurrent oral genital ulcers (OGU) are the main symptoms of Behcet’s syndrome but are often isolated manifestations. Most treatments (including high-dose corticosteroids and cytotoxic drugs) do not work well. The authors treated 15 cases of severe OGU with a response to stop the success, and the possible role of stopping the reaction mode made some exploration. Response to OGU curative effect has been reported, but the mechanism is unknown. Sheskin (1965) responded effectively to neoplastic leprosy reactions, which are characterized by accumulation of neutrophils and damage to immune complexes in the skin. Jorizzo and others argue that other effects of altrethan and Behcet syndrome have similarities with the leprosy response mechanism. The authors therefore reported on the clinical efficacy and used two rat models to investigate the effects of thalidomide on neutrophil accumulation in inflammatory lesions.