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目的:对比研究无创双水平压力触发（BiPhasic tr）对早产儿呼吸窘迫综合征（RDS）患儿氧合指数（OI）、氧气分压及机械通气使用率的影响。方法:回顾性分析广东省汕头市大峰医院2018年3月至2019年5月收治的100例RDS早产儿的临床资料。其中，采用鼻持续气道正压（NCPAP）治疗56例（对照组），采用BiPhasic tr治疗44例（观察组）。比较两组呼吸支持前后OI、动脉血氧分压（PaOn 2）、动脉血二氧化碳分压（PaCOn 2）及辅助通气时间、机械通气使用率、并发症发生率。n 结果:两组呼吸支持前PaOn 2、PaCOn 2和OI比较差异无统计学意义（n P>0.05）；两组呼吸支持后1、6、12和24 h PaOn 2、PaCOn 2、OI较呼吸支持前明显改善，且观察组改善程度明显优于对照组，差异有统计学意义（n P<0.05）。观察组辅助通气时间、机械通气使用率和并发症发生率明显小于对照组[（52.41 ± 16.53）h比（57.42 ± 17.82）h、11.36%（5/44）比19.64%（11/56）和15.91%（7/44）比33.93%（19/56）]，差异有统计学意义（n P0.05); the PaOn 2, PaCOn 2 and OI 1, 6, 12 and 24 h after respiratory support in 2 groups were significantly improved compared with those before respiratory support, and the improvement degree in observation group were significantly better than those in control group, and there were statistical differences (n P<0.05). The duration of auxiliary ventilation, utilization rate of mechanical ventilation, incidence of complication in observation group were significantly lower than those in control group: (52.41 ± 16.53) h vs. (57.42 ± 17.82) h, 11.36% (5/44) vs. 19.64% (11/56) and 15.91% (7/44) vs. 33.93% (19/56), and there were statistical differences (n P<0.05).n Conclusions:BiPhasic tr can effectively improve the oxygenation state, reduce the use rate of mechanical ventilation and carbon dioxide retention, reduce the incidence of complications such as intraventricular hemorrhage and so on in the treatment of RDS premature infants.