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目的探讨血液指标对α-地中海贫血(-SEA/α)妊娠患者的临床诊断价值。方法选取宜宾市第四人民医院2014年9月—2016年3月收治的-SEA/α妊娠患者5例作为观察组,另选取同期健康妊娠者20例作为对照A组,选取-SEA/α非妊娠患者5例作为对照B组,选取正常贫血妊娠患者20例作为对照C组。检测比较4组患者血液指标[红细胞平均体积(MCV)、血红蛋白(Hb)、红细胞计数(RBC)、红细胞分布宽度变异系数(RDW-CV)、RBC/MCV、RBC/Hb、血红蛋白A_2(HbA_2)],并检测-SEA/α基因。结果 4组患者各项血液指标比较,差异有统计学意义(P<0.05);其中观察组MCV高于对照B组,RBC/Hb低于对照B组(P<0.05);观察组患者RBC、MCV低于对照C组,Hb、RBC/MCV、RBC/Hb高于对照C组(P<0.05)。各项血液指标对于-SEA/α诊断价值结果显示,RBC/Hb、MCV曲线下面积最高,HbA_2最小;RBC/Hb诊断灵敏度与MCV相当,其次为RDW-CV、RBC/MCV;RBC/Hb与MCV诊断特异度较高,RBC最低。结论 -SEA/α妊娠患者的血液指标存在明显特征,通过血常规检查,并结合不同血液指标可有效提高筛查准确性。
Objective To investigate the clinical value of blood markers in pregnancy with α-thalassemia (-SEA / α). Methods Five cases of -SEA / α pregnancy treated by the Fourth People’s Hospital of Yibin from September 2014 to March 2016 were selected as the observation group. Another 20 healthy pregnant women were selected as the control group A, and -SEA / α was selected Five pregnant women as control group B, 20 normal pregnancy patients were selected as control group C. Blood samples were collected and compared among the four groups (MCV, RBC, RDW-CV, RBC / MCV, RBC / Hb and HbA 2) ], And detecting the -SEA / α gene. Results Compared with control group B, the RBC / Hb in observation group was lower than that in control group B (P <0.05); The observation group’s RBC, MCV was lower than control group C, and Hb, RBC / MCV and RBC / Hb were higher than control group C (P <0.05). The diagnostic value of each blood index for -SEA / α showed that RBC / Hb and MCV had the highest area under the curve and the lowest HbA_2. The diagnostic sensitivity of RBC / Hb was similar to MCV, followed by RDW-CV, RBC / MCV, RBC / Hb and MCV diagnosis of high specificity, lowest RBC. Conclusions-SEA / α pregnancy patients have obvious blood parameters, through blood tests, combined with different blood indicators can effectively improve the screening accuracy.