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本文采用尿蛋白肌酐指数(PCI)研究自身免疫性甲状腺疾病(AITD)中蛋白尿的发生率。PCI>150者为蛋白尿,结果135例AITD患者中蛋白尿发生率为29.6％。2h与24h尿PCI显著正相关,提示2小时尿PCI检测有其实用价值。PCI与甲状腺功能状态、循环免疫复合物及甲状腺抗体水平无关。在AITD中极轻微的免疫复合物性肾小球肾炎很可能是蛋白尿发生的主要原因。
Urinary protein creatinine index (PCI) was used to investigate the incidence of proteinuria in autoimmune thyroid disease (AITD). Patients with PCI> 150 had proteinuria, with a proteinuria rate of 29.6% in 135 AITD patients. 2h and 24h urinary PCI significant positive correlation, suggesting that 2-hour urinary PCI test has its practical value. PCI has nothing to do with thyroid function status, circulating immune complexes and thyroid antibody levels. Very minor immune complex glomerulonephritis in AITD is probably the main cause of proteinuria.