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近十几年来,随着免疫学的发展,对系统性红斑狼疮(SLE)的研究有了进一步深入,在SLE病人血清中陆续发现多种自身抗体,并且对这些自身抗体与临床特征的关系进行了详尽的研究,逐步形成了根据临床特征与血清学检查相结合,合理地划分SLE亚型。本文就Ro(SS-A),La(SS-B,Ha)这两对自身抗原——抗体系统与SLE亚型的关系综述如下: 一、抗原研究 1969年Clark等从人脾提取物(HSE)中,首次检出一种可溶性细胞抗原成分,命名为Ro,发现大约25％的SLE病人血清中
In the past ten years, with the development of immunology, the research of systemic lupus erythematosus (SLE) has been further studied. A series of autoantibodies have been found in the serum of patients with SLE, and the relationship between these autoantibodies and clinical features A detailed study, and gradually formed based on clinical features and serological tests combined to rational classification of SLE subtypes. In this paper, Ro (SS-A), La (SS-B, Ha) these two pairs of autoantigen-antibody system and SLE subtypes of the relationship are summarized as follows: First, antigen research Clark in 1969 from human spleen extract (HSE ), For the first time a soluble cellular antigenic component was detected and named Ro and found that about 25% of SLE patient serum