Dose evaluation of therapeutic radiolabeled bleomycin complexes based on biodistribution data in wil

• 作 者: Hassan Yousefnia Samaneh Zolghadri Amir Reza Jalilian Mohammad Ghannadi-Maragheh
• 机 构: Nuclear Science and Technology Research Institute (NSTRI),
• 出 处: Nuclear Science and Techniques
• 发表日期: 2015年06期
• 关键词: absorbed organs complexes seeking antibiotics labeled injected programs consider

Bleomycins(BLMs), as tumor-seeking antibiotics, have been used for over 20 years in treatment of several types of cancers. Several radioisotopes are used in radiolabeling of BLMs for therapeutic and diagnostic purposes. An important points in developing new radiopharmaceuticals, especially therapeutic agents, is the absorbed dose delivered in critical organs. In this work, absorbed dose to organs after injection of ~(153)Sm-,~(177)Lu- and ~(166)Ho-labeled BLM was investigated by radiation dose assessment resource(RADAR) method based on biodistribution data in wild-type rats. The absorbed dose effect of the radionuclides was evaluated. The maximum absorbed dose for the complexes was observed in the kidneys, liver and lungs. For all the radiolabeled BLMs,bone and red marrow received considerable absorbed dose. Due to the high energy beta particles emitted by ~(166)Ho, higher absorbed dose is observed for ~(166)Ho-BLM in the most organs. The reported data can be useful for the determination of the maximum permissible injected activity of the radiolabeled BLMs in the treatment planning programs.

Bleomycins (BLMs), as tumor-seeking antibiotics, have been used for over 20 years in treatment of several types of cancers. Several radioisotopes are used in radiolabeling of BLMs for therapeutic and diagnostic purposes. An important points in developing new radiopharmaceuticals, especially therapeutic In this work, absorbed dose to organs after injection of ~ (153) Sm-, ~ (177) Lu- and ~ (166) Ho-labeled BLM was investigated by radiation dose assessment The absorbed dose effect of the radionuclides was evaluated. The maximum absorbed dose of the complexes was observed in the kidneys, liver and lungs. For all the radiolabeled BLMs, bone and Due to the high energy beta particles emitted by ~ (166) Ho, higher absorbed dose is observed for ~ (166) Ho-BLM in the most organs. The reported data can be useful for the determinati on of the maximum permissible injected activity of the radiolabeled BLMs in the treatment planning programs.