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睾丸生殖细胞肿瘤是严重危害青壮年男性身体健康的疾病,目前其病因尚未探明;睾丸生殖细胞肿瘤发病年龄较早、没有明确环境致癌因素、存在明显种族发病差异、有较高遗传度;因此从人群肿瘤遗传易感性角度着手研究,更有助于探究发现其病因,为筛查、诊断、预防及治疗提供依据。利用基于单核苷酸多态性的全基因组关联研究等研究方法,近来国外发现了多个睾丸生殖细胞肿瘤发病相关基因,使睾丸生殖细胞肿瘤的遗传易感性研究取得了重要的进展。
Testicular germ cell tumors are serious diseases that endanger the health of males and young adults. At present, the etiology of testes has not been elucidated. Testicular germ cell tumors are older and have no definite environmental carcinogenic factors. There are obvious differences in ethnic origin and high heritability. Therefore, From the perspective of population genetic susceptibility to start the study, but also help to explore the etiology found, to provide the basis for screening, diagnosis, prevention and treatment. Recent research on genome-wide association studies based on single nucleotide polymorphisms (SNPs) has led to the discovery of multiple genes associated with germ cell tumors in the testes in foreign countries and made important advances in genetic susceptibility testicular germ cell tumors.