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目的 将血清胸苷激酶1(TK1)与现有的其他胃癌预后因子进行比较,评价其在胃癌预后领域的潜在应用价值,再通过3-5年的随访跟踪及Cox回顾分析结果,评价各预后指标的实际应用价值,为胃癌的防治选择最佳预后指标.方法 采用回顾性分析方法,收集从2011G4-2016G1就诊于我院胃肠外科经胃镜活检证实的胃癌患者共210例.应用免疫组织化学染色法检测61例胃癌组织中血清TK1表达,并将其与患者的性别、年龄、肿瘤大小、组织分化程度、TNM分期、浸润深度以及淋巴结转移情况进行相关性分析.结果 血清TK1Ⅳ期组与Ⅰ、Ⅱ期组之间比较、分化程度组间的比较、浸润深度比较、淋巴转移组与未转移组之间比较均有差异有统计学意义(P>005).且血清中TK1阳性率为577%,CEA阳性率为433%,CA199阳性率为288%,CA724阳性率为144%,CA50阳性率为269%,TK1阳性率明显高于其他四种肿瘤标志物.结论 血清TK1在胃癌中的预后具有正相关,说明胃癌分期、浸润深度和淋巴结转移情况是影响胃癌预后的最重要的独立危险因子.
Objective To compare the potential value of serum TK1 with other existing gastric cancer prognostic factors and evaluate its potential value in the prognosis of gastric cancer. Follow-up of 3-5 years and Cox retrospective analysis were performed to evaluate the prognosis Index of the practical application value for the prevention and treatment of gastric cancer to choose the best prognostic indicators.Methods A retrospective analysis of collected from 2011G4-2016G1 treatment in our hospital gastrointestinal surgery gastroscopy biopsy confirmed a total of 210 cases of gastric cancer patients.Immunohistochemistry The expression of TK1 in 61 cases of gastric cancer was detected by staining, and the correlation was analyzed with the gender, age, tumor size, histological grade, TNM stage, depth of invasion and lymph node metastasis.Results The serum level of TK1Ⅳ (P> 0.05), and the positive rate of TK1 in serum was 577 (P <0.05), and the difference between the two groups was statistically significant %, The positive rate of CEA was 433%, the positive rate of CA199 was 288%, the positive rate of CA724 was 144%, the positive rate of CA50 was 269%, the positive rate of TK1 was significantly higher than the other four tumor markers.Conclusion Serum TK1 in gastric cancer has a positive correlation, indicating that gastric cancer staging, depth of invasion and lymph node metastasis is the prognosis of gastric cancer prognosis of the most important independent risk factors.