M_1，M_2受体激动剂和阻滞剂对犬呼吸的影响

• 作 者: 姚兵 葛晓群 郑加林 秦伟 卞春甫
• 机 构: 徐州医学院药理教研室
• 出 处: Acta Pharmacologica Sinica
• 发表日期: 1996年03期
• 关键词: 阻滞剂 受体激动剂 M_1 M_2 哌仑西平 匹鲁卡品 呼吸换能器 呼吸抑制作用 去甲 多导生理记录仪

目的：研究Ｍ１和Ｍ２受体激动剂和阻滞剂对犬呼吸的影响．方法：用ＲＭ８６多导生理记录仪通过胸带式呼吸换能器测定ＲＲ，ＴＶ和ＭＶＶ，并取动脉血测ｐＯ２，ｐＣＯ２和ｐＨ．结果：发现Ｍ１Ｒ激动剂Ｐｉｌ和Ｍ２Ｒ激动剂６βＡＮｉｖ或椎动脉给药分别产生呼吸兴奋和抑制，ＲＲ，ＭＶＶ增高或降低（Ｐ＜００５），血气亦出现相应变化．Ｍ１Ｒ阻滞剂Ｐｉｒ，Ｓｃｏ和Ｍ２Ｒ阻滞剂ＡＦＤＸ１１６，Ａｔｒ分别拮抗甚至翻转Ｐｉｌ的呼吸兴奋和６βＡＮ的呼吸抑制作用．结论：激动呼吸中枢Ｍ１Ｒ呼吸兴奋，激动呼吸中枢Ｍ２Ｒ呼吸抑制，阻断之则作用相反．

Objective: To investigate the effects of M1 and M2 receptor agonists and blockers on canine breathing. Methods: RR, TV and MVV were measured by chest-band respiration transducer with RM86 multi-channel physiology recorder, and pO2, pCO2 and pH were measured by arterial blood flow. Results: It was found that M1R agonist Pil and M2R agonist 6βANiv or vertebral artery administration induced respiratory excitement and inhibition, RR, MVV increased or decreased (P <0  05), blood gas also appeared corresponding changes. M1  R blockers Pir, Sco and M2  R blockers AF  DX116, Atr antagonize and even reverse Pil respiratory excitement and 6β  AN respiratory depression. Conclusion: Excited respiratory center M1  R respiratory excitement, excitement respiratory center respiratory inhibition M2  R, blocking the opposite effect.