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文章介绍了HIV－1中和抗体研究的最新进展，并对以下几个方面展开了讨论：①分析了影响抗体中和作用评价效果的原因，其中主要是目前用于检测抗体中和作用的HIV多来自于CD4＋TCLA（T-cell－line-adapted）的分离物或TCLA病毒的克隆。由于这些病毒对抗体和可溶性CD4的敏感性比来
This article introduces the latest progress of research on HIV-1 neutralizing antibody and discusses the following aspects: (1) Analyze the reasons that affect the evaluation of antibody neutralization effect, mainly the HIV currently used to detect the role of antibody neutralization Mostly from CD4 + TCLA (T-cell-line-adapted) isolates or TCLA virus clones. Because of the sensitivity of these viruses to antibodies and soluble CD4