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目的观察抗结核药4种固定剂量复合制剂(FDC)引起药物性肝炎,监测不良反应发生,对结核病控制工作具有重要意义。方法对抗结核药4种固定剂量复合制剂(FDC)引起药物性肝炎的1例患者进行描述分析。结果抗结核药4种固定剂量复合制剂(FDC)引起药物性肝炎。结论虽然(FDC)抗结核药具有化疗方案合理规范、便于规律用药、良好的依存性等优点,应提高对抗结核药不良反应的认识、加强督导管理、及早发现不良反应,避免造成严重后果,应停用抗结核药而导致产生耐药性。
Objective To observe the drug-induced hepatitis caused by four kinds of fixed-dose combination (FDC) anti-TB drugs and monitor adverse reactions, which is of great significance for the control of tuberculosis. Methods One patient with drug-induced hepatitis induced by four kinds of fixed-dose combination (TBC) drugs against tuberculosis was described and analyzed. Results Anti-TB drugs Four fixed-dose combinations (FDCs) caused drug-induced hepatitis. Conclusions Although FDC anti-TB drugs have the advantages of reasonable standardization of chemotherapy regimen, convenient medication regularly and good dependence, they should raise their awareness of adverse reactions to TB drugs, strengthen supervision and management, detect adverse reactions as soon as possible and avoid serious consequences. Stop using anti-TB drugs and lead to drug resistance.