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过去五十年生理学以及临床研究提示,急性心肌便塞患者,早期输注葡萄糖—胰岛素—氯化钾(GIK)液,可缩小梗塞范围,抑制游离脂肪酸(FFA),保持组织、解剖结构,离子浓度和心肌磷酸化合物。 Stanley等研究,对具有冠状动脉症病的患者,输注GIK前及30分钟后,分别于动脉与冠状窦测定葡萄糖、乳酸及FFA。结果葡萄糖利用增加200％,FFA利用降低90％,乳酸利用增加100％。研究发现,空腹时呼吸商是0.70,输注GIK后则为0.93,提示脂肪代谢移向碳水化合物
Physiological and clinical studies over the past 50 years suggest that early infusion of glucose-insulin-potassium chloride (GIK) in patients with acute myocardial infarction may reduce infarct size, inhibit free fatty acids (FFA), preserve tissue, anatomy, Concentration and myocardial phosphate compounds. Stanley et al. In patients with coronary artery disease, glucose, lactate, and FFA were measured in the arteries and coronary sinus, respectively, 30 and 30 minutes prior to infusion of GIK. As a result, glucose utilization increased 200%, FFA utilization decreased 90%, and lactate utilization increased 100%. The study found that fasting respiratory quotient was 0.70, 0.93 after infusion of GIK, suggesting that fat metabolism to carbohydrates