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在先前实验(鹤草酚大鼠体内分布和鹤草酚静脉乳药物动力学研究)的基础上,设计了一个线性、血流限速的生理药物动力学模型。通过电子计算机模拟鹤草酚在大鼠体内的分布与消除。本模型包含血浆、脾、肾、肝、心、大脑和肌肉。平衡透析实验测得鹤草酚与血浆蛋白结合率为74%。模型中的生理参数取自文献值。生理药物动力学模型采用变步长RungeKutta法求数值解,计算机同时绘出组织浓度-时间曲线。除大脑在曲线末端稍有差异外,其它组织的模拟结果与实测均值吻合较好。将此大鼠生理模型外推用于家犬,血浆药物浓度模拟值能反映实测值的变化趋势。
Based on previous experiments (in vivo distribution of agrimony rats and pharmacokinetics of agromycin venous milk), a linear, blood flow rate-limiting physiological pharmacokinetic model was designed. The distribution and elimination of agrophenol in rats were simulated by computer. This model contains plasma, spleen, kidney, liver, heart, brain, and muscle. Equilibrium dialysis experiments showed that the binding of agromycin and plasma proteins was 74%. The physiological parameters in the model were taken from the literature values. The physiological pharmacokinetic model uses the variable step RungeKutta method for numerical solution, and the computer draws the tissue concentration-time curve. Except that the brain is slightly different at the end of the curve, the simulation results of other tissues are in good agreement with the measured mean values. The physiological model of this rat was extrapolated to the dog. The simulated plasma drug concentration can reflect the trend of the measured value.