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目的 探讨可能影响α 干扰素 (IFN α)中和抗体 (NA)产生的有关因素。方法 采用抗病毒中和生物测定法 (ANB)检测 1 1 6例IFN α治疗的慢性病毒性肝炎患者血清中的NA。结果 IFN α治疗前ALT(基础ALT)高水平组NA阳性率明显低于基础ALT低水平组 (P <0 .0 5) ,病毒阴转率则高于后者 (P <0 .0 5)。而乙型肝炎与丙型肝炎、男性与女性、年龄高低三者各NA阳性率也分别有所不同 ,但均无统计学差异 (P >0 .0 5)。结论 NA的产生与患者感染病毒类型 (乙或丙肝病毒 )、性别差异及年龄高低无明显关系 ,但与基础ALT水平的高低有关。基础ALT高水平者NA产生率较低 ,IFN疗效较好。此有助于IFN治疗的临床病例选择。
Objective To explore the factors that may affect the production of neutralizing antibodies (NA). Methods The serum levels of NA in 116 patients with chronic viral hepatitis treated with IFNα were detected by antiviral neutralization bioassay (ANB). Results The positive rate of NA in high ALT (basic ALT) group before IFN α treatment was significantly lower than that in low ALT (P <0.05), and the negative rate of virus was higher than the latter (P <0.05) . The positive rate of each NA of hepatitis B and hepatitis C, male and female, and age was also different, but there was no significant difference (P> 0.05). Conclusions There is no significant relationship between NA production and virus type (hepatitis B or C), gender difference and age, but it is related to the level of basic ALT. The basic ALT high level of NA production rate is lower, IFN curative effect is better. This contributes to the clinical choice of IFN therapy.