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对排除自身免疫性疾病 ,经胃镜诊断为慢性浅表性胃炎 (CSG)、慢性萎缩性胃炎 (CAG)和消化性溃疡 (PU)共 86例病人的活检胃粘膜进行Warthin Starry银染和快速尿素酶试验 ,以确定有否幽门螺杆菌 (Hp)感染 ;用HE染色和免疫组织化学染色方法观察T、B淋巴细胞的增生以及淋巴滤泡形成。结果表明 ,在Hp感染病人中 (5 9例 ,6 8 6 % ) ,有淋巴滤泡者占 35 6 % (2 1/ 5 9) ,发现 6例淋巴上皮病变。而无Hp感染的病人均无淋巴滤泡。Hp感染的有无和感染程度与淋巴细胞浸润、淋巴滤泡形成和慢性活动性胃炎呈显著相关 (P <0 0 1)。结果提示 ,Hp感染与粘膜相关淋巴组织 (MALT)淋巴瘤的发生有关。临床上有必要对存在胃淋巴滤泡 /MALT的病人进行Hp根除治疗。
A total of 86 patients with autoimmune disease, 86 patients diagnosed as chronic superficial gastritis (CSG), chronic atrophic gastritis (CAG) and peptic ulcer (PU) by gastroscope were treated with Warthin Starry silver staining and rapid urea Enzyme test to determine whether Helicobacter pylori (Hp) infection; observed by HE staining and immunohistochemical staining of T, B lymphocyte proliferation and lymphoid follicle formation. The results showed that in patients with Hp infection (59 cases, 686%), those with lymphatic follicles accounted for 35.6% (21/59), and 6 cases of lymphoepithelial lesions were found. No Hp infection in patients with lymphoid follicles. The presence of Hp infection and the degree of infection were significantly associated with lymphocytic infiltration, lymphoid follicular formation and chronic active gastritis (P <0.01). The results suggest that Hp infection is associated with the development of mucosa-associated lymphoid tissue (MALT) lymphoma. It is clinically necessary for Hp eradication in patients with gastric lymphatic follicles / MALT.