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血栓调理素(TM)是由血管内皮细胞产生,与凝血酶结合后,抑制凝血活性,通过C蛋白介导具有抗凝作用的一种糖蛋白,正常健康者血中亦存在TM。作为一种血管内皮细胞损伤标志物的TM正引起学者们注意。但对糖尿病TM研究至今尚未见有报道,为此作者进行研究,观察TM与糖尿病合并症的相关性。共收集40例糖尿病患者,男17例,女23例。平均年龄分别为59.5±2.5岁和52.9±3.3岁。另8例健康男性,平均年龄35.3±1.8岁为对照组。空腹采血,按石井氏一步夹心EIA法测定血浆TM。
Thrombomodulin (TM), which is produced by vascular endothelial cells and binds to thrombin, inhibits coagulation activity and mediates an anticoagulant glycoprotein through protein C, also present in normal healthy blood. As a marker of vascular endothelial cell damage, TM is attracting attention. However, no research on diabetes TM has been reported so far. To this end, the author studied the relationship between TM and diabetic complications. A total of 40 cases of diabetic patients, 17 males and 23 females. The average age was 59.5 ± 2.5 years and 52.9 ± 3.3 years, respectively. Another 8 healthy men, with an average age of 35.3 ± 1.8 years as the control group. Fasting blood, according to Ishii’s one-step sandwich EIA method for the determination of plasma TM.