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小肠细菌过度生长可影响肠内多种重要营养物质的吸收而引起吸收不良综合症,受到重视~([1])。本症传统上多采用抽吸小肠内容物进行细菌培养来确诊,但需插管,不为病员所欢迎;而且一些拟杆菌属或其它厌氧杆菌的培养均较困难,化费昂贵,培养结果往往也不一定能反映肠菌生长的真实情况~(2,3)。因此,近年较多研究均旨在寻找有效的非侵入性间接方法来明确肠菌生长情况,其中尤以呼吸试验得到较大发展~(3),兹简介如下: 一、CO_2呼吸试验:正常人小肠上部相对无菌(空肠中部69%无菌),由胆道进入肠内的胆汁(结合胆盐)大部分在末端回肠被重吸收进行肠肝循环,仅有少量在结肠内被细菌水解成游离牛磺酸或甘氨酸及其游离胆酸(脱结合胆盐),井可进一步被代谢成CO_2经肠粘膜吸收入血而由肺呼出。因此,当口服一定量结合胆
Small intestine bacterial overgrowth can affect the absorption of a variety of important nutrients in the intestine caused by malabsorption syndrome, attention [1]. Traditionally, the disease is diagnosed by bacterial culture of the aspiration of small intestine, but intubation is not welcomed by the patient; moreover, some Bacteroides or other anaerobic bacteria are more difficult to culture and costly to culture Often do not necessarily reflect the true growth of enterobacteria ~ (2,3). Therefore, in recent years, more studies are aimed at finding an effective and non-invasive indirect method to determine the growth of enterobacteriaceae. Breathing tests have been greatly developed ~ (3), which is as follows: First, CO 2 respiration test: normal The upper part of the small intestine is relatively sterile (69% sterile in the middle part of the jejunum). Most of the bile (bound bile salts) entering the intestine through the biliary tract is reabsorbed in the distal ileum for enterohepatic circulation. Only a small amount is hydrolysed in the colon by bacteria Taurine or glycine and its free cholic acid (debonded bile salts), well can be further metabolized into CO_2 by the intestinal mucosa absorbed into the blood exhaled by the lungs. Therefore, when combined orally with a certain amount of gall