论文部分内容阅读
正常成人葡萄糖产生的速度是由胰岛素和胰高血糖素的相互作用来调节的。当输注葡萄糖时,由于胰岛素作用于肝脏,抑制了内源性葡萄糖的产生。输注速度快时,胰岛素浓度增加可完全抑制了葡萄糖的产生。新生儿出生后葡萄糖代谢发生了急剧转变。在适应这种转变中,早产儿和小于胎龄儿(SGA)均可发生体内葡萄糖平衡的改变,而在输注葡萄糖时发生低血糖或高血糖。其紊乱的机理尚未充分了解。本文通过对健康的8例适龄儿(AGA),5例早产儿及6例SGA从四肢周围静脉输注葡萄糖2.6～4.6mg/kg/min,并用同位素示踪方法进行葡萄糖动力学测定,藉以监测血糖浓度在调节新生儿内源性葡萄糖生成中的作用。于禁食6小时后进行检查,结果在未输注前,婴儿的内源性葡萄糖生成速率足月(AGA)与早产儿是相近的(前者3.53±0.32,后者3.49±0.38mg/kg/min),但SGA比AGA高(P<0.03)。
The rate of normal adult glucose production is regulated by the interaction of insulin and glucagon. When glucose is infused, the production of endogenous glucose is inhibited by the action of insulin on the liver. Infusion speed, the increase in insulin concentration can completely inhibit the production of glucose. After the birth of newborns glucose metabolism has undergone dramatic changes. In adapting to this shift, changes in the body’s glucose balance can occur in both preterm infants and small gestational age children (SGA), while hypoglycemia or hyperglycemia occurs when glucose is infused. The mechanism of its disorder is not fully understood. In this paper, glucose (2.6-6.6mg / kg / min) was infused into healthy peripheral blood of 8 cases of AGA, 5 cases of premature infants and 6 cases of SGA by peripheral venous extremities, and glucose was determined by isotope tracer method The role of blood glucose concentration in regulating neonatal endogenous glucose production. After 6 hours of fasting, the infants were examined for end-stage glucose production at full-term (AGA) and preterm infants (3.53 ± 0.32 for the former, 3.49 ± 0.38 mg / kg / min), but SGA was higher than AGA (P <0.03).