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目的评估皮肤AGE无创检测技术在糖尿病筛查中的应用价值。方法选取208例T2DM患者和119名健康体检者行体征检查、生化检测,采用基于AGE光学检测技术的糖尿病无创检测仪(DM Scan)对受试者上臂皮肤组织中的AGE进行无创检测,采用受试者工作特征(ROC)曲线评价其敏感性和特异性。结果≤30岁、30~50岁和≥50岁糖尿病患者AGE均高于健康受试者[(56.2±4.1)vs(71.3±8.4)AU、(62.0±5.9)vs(70.6±6.2)AU、(62.5±6.9)vs(75.8±8.4)AU](P<0.01)。Pearson相关分析显示,AGE与FPG(r=0.417,P<0.01)和HbA_1c(r=0.500,P<0.01)相关。多元回归分析显示,AGE值与糖尿病发病风险密切相关[OR1.322,95%CI(1.228,1.424),P<0.01]。DM Scan检测皮肤AGE的ROC为0.941[95%CI(0.917,0.965)],AGE切点65.00AU时对应的敏感性为88.5%,特异性为89.9%。结论 DM Scan检测皮肤AGE筛查T2DM有较高的敏感性和特异性,有望成为一种新的无创糖尿病筛查工具。
Objective To assess the value of skin AGE noninvasive detection in diabetic screening. Methods Totally 208 T2DM patients and 119 healthy volunteers were examined for signs and biochemical tests. The noninvasive detection of AGE in the upper arm skin tissues of the subjects was performed using the DM Scan based on the AGE optical detection technique. The receiver operating characteristic (ROC) curve was used to evaluate the sensitivity and specificity. Results AGE in patients ≤30 years, 30-50 years and ≥50 years was significantly higher than that in healthy subjects [(56.2 ± 4.1) vs (71.3 ± 8.4) AU, (62.0 ± 5.9) vs (70.6 ± 6.2) AU, (62.5 ± 6.9) vs (75.8 ± 8.4) AU] (P <0.01). Pearson correlation analysis showed that AGE was correlated with FPG (r = 0.417, P <0.01) and HbA_1c (r = 0.500, P <0.01). Multivariate regression analysis showed that the AGE value was closely related to the risk of diabetes [OR1.322, 95% CI (1.228, 1.424), P <0.01]. The ROC of DM Scan was 0.941 [95% CI (0.917,0.965)] for AGE and 88.5% for AGE at 65.00 AU, with a specificity of 89.9%. Conclusion The high sensitivity and specificity of DM Scan in the screening of skin AGE for T2DM are expected to become a new noninvasive diabetes screening tool.