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移植肾早期无功能(PNF)经常发生,据报道,发病率为76%,而且PNF继发排斥与其他原因导致的移植肾功能减退很难鉴别,作者通过冷藏前及移植时二次肾灌洗排除肾活性复合物,降低PNF的发生。作者从1986、6～1988、1前瞻性研究145例肾移植病人。1986、、6～1987、6原位肾灌洗后冰块冷藏并直接移植给病人(106例,Ⅰ组);1987、6～1988、1上述方法处理后,移植前用冰冷的Travenol灌洗液500毫升再次灌洗(“后灌洗”)(39例,Ⅱ组)。除Ⅰ组中13例病人外,均采用环孢素负荷量15mg/kg,术后减少到10mg/kg,其后环孢素血浓度保持在200～400ng/ml;强的松龙25mg/日口服;急性排斥用甲基强的松龙500mg,连续三日静点。未用环孢素的13例应用硫唑嘌呤和强的松龙。PNF定义为:移植术后头7天需透析治疗。
Early renal allograft function (PNF) occurs frequently, the incidence is reported to be 76%, and PNF secondary rejection and other causes of graft dysfunction is difficult to identify, the author through the two cold before renal transplantation and transplantation Exclude the renal active complex, reduce the incidence of PNF. The authors from 1986,6 ~ 1988,1, prospective study of 145 cases of kidney transplant patients. 1986, 6 ~ 1987, 6 after in situ renal lavage cold storage and direct transplantation of the patient (106 cases, group Ⅰ); 1987,6 ~ 1988,1,8 after the above method, before transplantation, with cold Travenol lavage Re-lavage 500ml liquid (“lavage after”) (39 cases, group Ⅱ). In addition to 13 patients in group I, were used cyclosporine loading 15mg / kg, reduced to 10mg / kg after surgery, followed by cyclosporine blood concentration was maintained at 200 ~ 400ng / ml; prednisolone 25mg / day Oral; acute rejection of methylprednisolone 500mg, for three consecutive days of static. Azathioprine and prednisolone were used in 13 cases without cyclosporine. PNF is defined as: Dialysis treatment for the first 7 days after transplantation.