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目的为更快速、高效、经济而安全地根除幽门螺杆菌（Ｈｐ），减少Ｈｐ耐药性和复发率．方法用四组对照的方法研究了二日疗法根除Ｈｐ及治疗Ｈｐ相关性消化性溃疡（ＰＵ）和非溃疡性消化不良（ＮＵＤ）的近期效果和随访结果．组１，４４例，口服雷尼替丁０１５ｇ，２次／ｄ；甲硝唑０４ｇ，３次／ｄ；丽珠得乐１０ｇ，４次／ｄ；４ｗｋ．组２，４４例，以奥美拉唑（２０ｍｇ，２次／ｄ）代替雷尼替丁，余同组１．组３，３７例，口服庆大霉素１６万Ｕ，３次／ｄ；雷尼替丁０３ｇ，２次／ｄ；羟氨苄青霉素０７５ｇ，３次／ｄ；丽珠得乐１０ｇ，４次／ｄ；２ｄ．组４，３４例，以四环素（０７５ｇ，４次／ｄ）代羟氨苄青霉素，余同组３．结果治疗后患者症状消失时间（ｄ）组３（２３±１２），组４（２４±１２）明显短于组１（６７±２５）和组２（６５±２７，Ｐ＜００１）．治疗１ｍｏ后Ｈｐ根除率组３（９７３％）及组４（９４１％）明显高于组１（７０５％）和组２（７２７％，Ｐ＜００１）．溃疡愈合率、炎症消失率四组无显著差异．随访６ｍｏ～３９ｍｏ，Ｈｐ再检出率四组分别为４５％，６８％，８１％和５９％．结论二日四联疗法根除Ｈｐ快速、?
The purpose is to eradicate Helicobacter pylori (Hp), reduce Hp resistance and relapse rate more rapidly, efficiently, economically and safely. Methods Four groups of controlled trials were conducted to investigate the short-term and follow-up results of two-day therapy for the eradication of Hp and for the treatment of Hp-associated peptic ulcer (PU) and non-ulcer dyspepsia (NUD). Group 1,44 cases, oral ranitidine 0 15g, 2 times / d; metronidazole 0 4g, 3 times / d; Livzon Dele 1 0g, 4 times / d; 4wk. Group 2,44 cases, with omeprazole (20mg, 2 times / d) instead of ranitidine, the same group 1. Group 3, 37 cases, oral gentamicin 160,000 U, 3 times / d; ranitidine 0 3g, 2 times / d; amoxicillin 0 75g, 3 times / d; 0g, 4 times / d; 2d. Group 4, 34 cases, tetracycline (0 75g, 4 times / d) on behalf of amoxicillin, the same group of 3. Results After treatment, the symptom disappearance time in group (d) was significantly shorter than group 1 (67 ± 25) and group 2 (23 ± 12), group 4 (24 ± 12) (65 ± 27, P <001). The rate of Hp eradication group 3 (973%) and group 4 (941%) were significantly higher than those in group 1 (705%) and group 2 (727%, P <001) after 1mo treatment. Ulcer healing rate, rate of disappearance of inflammation no significant difference between the four groups. Follow-up 6mo ~ 39mo, Hp re-detection rate of four groups were 45%, 68%, 81% and 59%. Conclusions Two-day quadruple therapy eradicates Hp rapidly ,?