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rac-Tetra(m-nitrobenzene)porphyrin, H_2TNO_2PP, synthesized from o-nitro-benzaldehyde and pyrrole was reduced to H_2TamPP, from which tetra(o-phenylacetyl benzene) porphyrin and especially its α,α,α,α-isomer were obtained. The α,α,α,α-isomer was used as hapten to immunize BALB/C mice. The latter gave antibody value of 320 as determined by ELISA method, indicating that the artificial hapten could induce the production of antibody without use of carrier.
rac-Tetra (m-nitrobenzene) porphyrin, H_2TNO_2PP, synthesized from o-nitro-benzaldehyde and pyrrole was reduced to H_2TamPP, from which tetra (o-phenylacetyl benzene) porphyrin and especially its α, α, α, The α, α, α-isomer was used as hapten to immunize BALB / C mice. The latter gave antibody by of as as determined by ELISA method, indicating that the artificial hapten could induce the production of antibody without use of carrier .