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本文总结了２７０４例ＨＣＶ有关的慢性肝病，并分析了各肝病包括肝细胞癌与ＨＣＶ亚型的关系。结果发现，１９２２例的慢性丙型肝炎中有１３０５例为ＨＣｖ－１ｂ关连型（１ｂ＋１ｂ与２ａ或２ｂ混合型），占７１．２％，在３５６例肝硬化及４２６例肝癌中，ＨＣＶ－１ｂ关连型的出现率分别为７９．８％（２８４／３５６）及８０．５％（３４３／４２６）。这明显高于慢性丙型肝炎中的ＨＣＶ－１ｂ关连型发生率，但肝硬化与肝癌组之间比较，ＨＣＶ－１ｂ关连型的发生率无差异。而肝硬化及肝癌组的ＨＣＶ－２ａ及２ｂ的发生率明显低于慢性丙肝组。这些结果提示，ＨＣＶ－１ｂ型较其他亚型具有更强的致病作用，可能与肝细胞癌的发生有密切的关系。
This article summarizes 2704 chronic liver diseases associated with HCV and analyzes the relationship between liver diseases including hepatocellular carcinoma and HCV subtypes. The results showed that 1,305 of the 1,192 cases of chronic hepatitis C were associated with HCv-1b (1b+1b and 2a or 2b), accounting for 71.2% of the cases, among 356 cases of liver cirrhosis and 426 cases of liver cancer, HCV-1b The incidence of related types was 79.8% (284/356) and 80.5% (343/426) respectively. This was significantly higher than the incidence of HCV-1b-associated type in chronic hepatitis C, but there was no difference in the incidence of HCV-1b-related type between cirrhosis and liver cancer groups. The incidence of HCV-2a and 2b in the liver cirrhosis and liver cancer group was significantly lower than that in the chronic hepatitis C group. These results suggest that HCV-1b has a stronger pathogenic effect than other subtypes and may be closely related to the occurrence of hepatocellular carcinoma.