,The BAH domain of BAHD1 is a histone H3K27me3 reader

• 作 者: Dan Zhao Xiaojie Zhang Haipeng Guan Xiaozhe Xiong Xiaomeng Shi Haiteng Deng Haitao Li
• 机 构: College of Life Sciences,Peking University,Beijing 100871,China“,”MOE Key Laboratory of Protein Scie
• 出 处: 蛋白质与细胞
• 发表日期: 2016年3期

Dear Editor,Histone recognition by reader modules constitutes a major mechanism for epigenetic regulation (Jenuwein and Allis 2001).BAHD1 (bromo adjacent homology domain containing protein 1) is a vertebrate-specific nuclear protein (Fig.S1) involved in gene silencing by promoting heterochromatin formation.BAHD1 is characteristic with an N-terminal proline-rich region,a nuclear localization signal motif,and a C-terminal bromo adjacent homology (BAH) domain (Fig.1A).