【摘 要】
：
Dear Editor,Many human genetic diseases are caused by pathogenic single nucleotide mutations.Animal models are often used to study these diseases where the path
【机 构】
：
Key Laboratory of Gene Engineering of the Ministry of Education, Guangzhou Key Laboratory of Healthy
论文部分内容阅读
Dear Editor,Many human genetic diseases are caused by pathogenic single nucleotide mutations.Animal models are often used to study these diseases where the pathogenic point mutations are created and/or corrected through gene editing (e.g.,the CRISPR/Cas9 system) (Komor et al.,2017;Liang et al.,2017).
其他文献
Dear Editor,Dysregulation of hepatic lipid and glucose production results in obesity,diabetes and nonalcoholic fatty liver disease.De novo lipogenesis and gluco
Dear Editor,Endocytosis is a crucial process employed by cells to intemalize nutrients and tumover membrane components and is essential for many functions,inclu
On Nov.1st 2016,a research paper titled Structural basis for DNA recognition by STAT6 was published online on PNAS (Li et al.,2016),which revealed for the first
Dear Editor,rnPotassium channels are integral membrane proteins that selectively conduct K+ ions across cell membrane (Hille, 2001). They play essential roles i
Dear Editor,Proline-rich antimicrobial peptides (PrAMPs) are a class of antimicrobial peptides containing a high content of proline residues.PrAMPs selectively
Dear Editor, Blockade of PD-1/PD-L1 signaling pathway by monoclonal antibodies (MAbs) to release the anti-tumor activity of preexisting tumor specific Tcell imm
Zika virus (ZIKV) is a mosquito-boe pathogen from the family Flaviviridae,and infection of humans with ZIKV through mosquito bites may result in a disease known
Dear EditorDengue fever (DF) is the most significant emerging arbovirus disease,which is caused by four distinct serotypes of Dengue viruses (DENV-1 to DENV-4).
Dear Editor,Long non-coding RNAs (IncRNAs),defined as RNA transcripts longer than 200 nucleotides without the protein-coding ability (Caminci et al.,2005),share
在引人注目的昆虫群体中，叶虫和竹节虫能够惟妙惟肖地假扮植物的颜色、形状的本领可不是一般的大。它们凭借高超的拟态技巧和聪明的御敌之术，被誉为“丛林幽灵”“伪装大师”。 繁衍至今的“活化石” 根据化石研究，竹节虫最早出现于2.51亿-2.05亿年前的三叠纪，与直翅目昆虫有很近的亲缘关系。然而几个独特的解剖学特征把它们和所有其他新翅类昆虫区别开来，表明它们是一个独立的群体：比如，所有竹节虫的前胸都有