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目的:观察七味三芎汤对动脉粥样硬化大鼠血清TNF-α、IL-6水平的影响,探讨其治疗AS的作用机制。方法:采用饲喂高脂饲料胃复制大鼠AS模型,以辛伐他汀为对照,观察七味三芎汤喂饲10周后各组大鼠血清TNF-α、IL-6水平。结果:七味三芎汤和辛伐他汀组大鼠血清TNF-α、IL-6水平均低于模型组。结论:七味三芎汤可降低血清TNF-α、IL-6水平,通过抗炎作用达到改善斑块的稳定性。
Objective: To observe the effect of Qiwei Sanxiong decoction on serum levels of TNF-α and IL-6 in atherosclerotic rats and to explore its mechanism of action in treating AS. Methods: The rat model of AS was fed with high-fat diet and the simvastatin was used as control. Serum levels of TNF-α and IL-6 of rats in each group were observed after 10 weeks of feeding. Results: The serum levels of TNF-α and IL-6 in the rats treated with Qiweisanxiong Decoction and simvastatin group were lower than those in the model group. Conclusion: Qiwei Sanxiong decoction can reduce the level of serum TNF-α and IL-6 and improve the plaque stability through the anti-inflammatory effect.