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目的 对比氯沙坦、依那普利及其合用对大鼠急性心肌梗死 (AMI)左室重塑的防治作用。方法 雌性SD大鼠经冠状动脉结扎致AMI,术后 48h存活的 83只随机分成 :(1)AMI对照组 ,(2 )氯沙坦 (3mg·kg-1·d-1)组 ,(3)依那普利 (1mg·kg-1·d-1)组 ,(4 )氯沙坦和依那普利合用 (3mg·kg-1·d-1和 1mg·kg-1·d-1)组 ;另设 :(5 )假手术组和 (6 )正常组作对照。在给药治疗 4周后均行血流动力学测定、心脏标本固定和病理分析。最终 5 6只大鼠获完整资料 ,上述各组分别为 11、10、10、11、6和 8只大鼠。结果 1～ 4组间MI面积 (4 1 7～ 43 4) %差异均无显著性 (P >0 0 5 )。与假手术组相比 ,AMI组左室舒张末期压 (LVEDP)、容积 (LVV)、长 (L)、短 (D)轴长度和左室实际重量 (LVAW)及相对重量 (LVRW)均显著增加 (P <0 0 5～ 0 0 0 1) ,发生了左室重塑 ;而左室内压最大上升和下降速率(±dp/dt)及其校正值均显著降低 (P均 <0 0 0 1)。与AMI对照组相比 ,氯沙坦、依那普利及其合用三个治疗组的LVEDP、LVV、LVAW和LVRW均显著降低或减小 (P <0 0 5～ 0 0 0 1) ;除氯沙坦组的 -dp/dt校正值外 ,±dp/dt校正值在三个治疗组均显著恢复 (P <0 0 5～ 0 0 0 1)。上述各指标在三个治疗组间差异均无显著性 (P均 >0 0 5 )。结?
Objective To compare the preventive and therapeutic effects of losartan, enalapril and their combination on left ventricular remodeling in acute myocardial infarction (AMI) in rats. Methods Female Sprague-Dawley rats were AMI-ligation after coronary artery occlusion and were randomly divided into three groups: (1) AMI control group, (2) losartan group (3 mg · kg-1 · d-1) ) Were treated with enalapril (1 mg · kg-1 · d-1), losartan plus enalapril (3 mg · kg-1 · d-1 and 1 mg · kg-1 · d-1 ); Another set: (5) sham operation group and (6) normal control. After 4 weeks of treatment, hemodynamics, heart specimen fixation and pathological analysis were performed. The final 5 6 rats were complete data, the above groups were 11,10,10,11,6 and 8 rats. Results There was no significant difference in MI area (4 1 7 ~ 43 4)% between 1 ~ 4 groups (P 0 05). LVEDP, LVV, length (L), length of short axis (D), left ventricular LVAW and LVRW in AMI group were significantly higher than those in sham operation group (P <0.05-0.001), left ventricular remodeling occurred, while the maximal rise and fall rate of left ventricular pressure (± dp / dt) and their corrected values were significantly decreased (all P <0 0 0 1). Compared with AMI control group, LVEDP, LVV, LVAW and LVRW in losartan, enalapril and their combination groups were significantly decreased or decreased (P <0.05-0.01) Except for the -dp / dt, the ± dp / dt of Losartan group was significantly higher in all three treatment groups (P <0.05-0.001). There was no significant difference among the three treatment groups (P> 0.05). Knot?