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目的探讨电击死亡皮肤损害及心肌免疫表达特征。方法对电击死亡尸检7例损伤皮肤及周围皮肤组织，5例心肌组织进行常规HE切片观察；皮肤EMA、E-Cadherin、心肌Actin、Myoglobin免疫抗体的标记，检测受电击后二种组织的阳性细胞表达，免疫染色方法为MaxVisiom二步法，阳性标准参照有关文献判定。结果7例电流损伤皮肤E M A表达数量、分布不一，或完全（-），或个别细胞（+），或灶状基底细胞到斑驳状（+），周围皮肤与电流斑表达大致相同；E-Cadherin在电流斑处依次呈（-），逐渐与周围过渡（+），胞浆内弥散，断续或不规则（+），到上皮正常表达。心肌Actin呈浆内斑点状（+）为主，亦见部分肌细胞浆内（+）；Myoglobin则较为规则，5例均为胞浆离位呈肌膜簇状颗粒（+）表达。结论人体电击死是局部皮肤直接损伤的全身病变。损伤皮肤及周围皮肤免疫改变是与通过人体电流的大小、持续的时间、途径、人体电阻及自身健康状况等多种因素有关。强电流冲击可致心肌胞浆的破坏特别是肌红蛋白胞浆离位肌膜颗粒状聚集，阻碍了心肌正常胞膜的生理功能。“,” Objective: To interrogate the injury of the skin of electrocuted individuals and the expression profiles of the myocardial immune system. Methods: HE stain was performed to observe 7 cases of electrocuted skin and surrounding tissues, as wel as 5 cases of cardiac muscle. Cutaneous EMA and E-Cadherin, and myocardial Actin and Myoglobin were detected using the MaxVisiom method (positive criteria see related references). Results: The expression levels and locations of cutaneous EMA in 7 cases of electrocuted skin vary dramatical y in different kinds of cel s. The expression patterns of surrounding tissues are similar to that of electronic marks. There is a transition in the expression of E-Cadherin from the electronic marks to surrounding tissues: in a diffused, interrupted, or irregular manner in the cytoplasm and in a normal manner in the epithelium. Myocardial Actin was expressed mainly in a dotted manner. Nevertheless, Myoglobin was expressed in a regular way: al the 5 cases were expressed as clusters of particles in a cytoplasmic off-normal manner. Conclusion: Electrocution leads to direct injuries of local skin systemical y. The immunological changes in the cutaneous lesion and surrounding tissues are correlated with numerous factors including electric current intensity, pulse duration, pathways, body resistance, and health conditions. The attack of intense electric current may cause damage to the myocardial cytoplasm especial y the cytoplasmic dislocation of myoglobin and aggregation of myolemma in a particle manner, blocking the normal physiological functions of cardiac muscle as cytoplasmic membranes.