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Wistar大鼠肠缺血／再灌注损伤后，血浆ET、CGRP水平明显升高（P＜0．05，P＜0．01）。PLA2阻断剂氯喹、消炎痛、三氟拉嗪于缺血／再灌注损伤前应用可明显延长损伤大鼠的存活时间，减轻肠缺血／再灌注时远端脏器肺组织的损伤，同时降低血浆ET、明显升高血浆CGRP水平。上述结果提示：ET、CGRP参与缺血／再灌注损伤过程。PLA2阻断剂可抑制损伤时ET释放，并通过某些环节促进机体释放CGRP，这可能是它们在此条件下，对机体保护作用的机制之一。
The levels of plasma ET and CGRP in Wistar rats were significantly increased after intestinal ischemia / reperfusion injury (P <0.05, P <0.01). The application of PLA2 blockers chloroquine, indomethacin and trifluoperazine before ischemia / reperfusion injury could prolong the survival time of injured rats and alleviate the damage to the lung tissues of distal organs during intestinal ischemia / reperfusion Lower plasma ET, significantly increased plasma CGRP levels. The above results suggest that: ET, CGRP participate in the process of ischemia / reperfusion injury. PLA2 blockers can inhibit the release of ET during injury and promote the release of CGRP through some aspects, which may be one of the mechanisms of their protective effect on the body under these conditions.