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采用玻璃微电极细胞外记录法，观察了清醒完整大鼠海马神经元自发放电对皮下注射福尔马林的反应。结呆显示，在海马CA2／CA3区可记录到痛兴奋、痛抑制和非痛敏三种神经元。同侧前爪皮下注射福尔马林后，痛兴奋神经元的自发放电显著增多，而痛抑制神经元的自发放电显著减少，这种变化在给予福尔马林后30min左右达到最大值，在60min左右恢复到对照水平；但在给予福尔马林后，非痛敏神经元的自发放电无明显变化。以上实验结果提供了在福尔马林痛模型中，海马在痛感受或痛反应过程中发挥一定作用的电生理证据。
Glass microelectrode extracellular recording method was used to observe the spontaneous discharge of hippocampal neurons in awake intact rats and the response to subcutaneous injection of formalin. Results show that in the hippocampal CA2 / CA3 area can be recorded pain excitement, pain inhibition and non-pain sensitivity of three neurons. After formalin injection into the ipsilateral forearm, spontaneous firing of pain-stimulated neurons increased significantly, while spontaneous firing of pain-inhibiting neurons decreased significantly, reaching the maximum at 30 min after formalin administration 60min return to the control level; but after formalin administration, spontaneous discharge of non-pain-sensitive neurons no significant change. The above experimental results provide electrophysiological evidence that the hippocampus plays a role in the pain sensation or pain response in the formalin pain model.